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目的分析2015年保定市手足口病病原分布特征,随访脱甲发生情况,了解不同病原分布对脱甲症的影响。方法采用实时荧光定量聚合酶链反应对病原进行检测,对肠道病毒阳性病例进行随访,从发病后连续观察3个月,筛选脱甲病例。结果 618例阳性病例中,5岁以下儿童Cox A6和其他肠道病毒交替成为主要病原,而5岁以上儿童则以EV 71为主。Cox A6构成比在北部、南部和中部之间差异不大(χ~2=4.369,P>0.05)。EV 71和Cox A16多集中在南部和中部(χ2=17.300,P<0.05;χ2=6.172,P<0.05),其他肠道病毒则集中在北部和中部(χ~2=15.242,P<0.05)。138例病例出现脱甲,脱甲发生率为22.33%。脱甲组Cox A6病原构成比高于未脱甲组(χ~2=100.856,P<0.05),EV 71、Cox A16及其他肠道病毒病原构成比低于未脱甲组(χ~2=19.724,P<0.05;χ~2=23.305,P<0.05;χ~2=8.855,P<0.05)。结论 Cox A6已成为保定市手足口病的主要病原与手足口病后脱甲症密切相关。
Objective To analyze the distribution of HFMD in Baoding City in 2015 and follow-up the incidence of dementia and understand the influence of different pathogens on demethyroidism. Methods The pathogen was detected by real-time fluorescence quantitative polymerase chain reaction (PCR). The positive cases of enterovirus were followed up for 3 months. The cases of dementia were selected. Results Among 618 positive cases, Cox A6 and other enteroviruses were the main pathogens alternately in children under 5 years of age, while those over 5 years old were predominantly EV 71. There was no significant difference in Cox A6 composition between North, South and Middle (χ ~ 2 = 4.369, P> 0.05). EV71 and Cox A16 were mostly concentrated in the southern and central regions (χ2 = 17.300, P <0.05; χ2 = 6.172, P <0.05) . 138 cases of cases of dementia, dementia rate was 22.33%. The constitutional ratio of Cox A6 in demethylation group was higher than that in non-dementia group (χ ~ 2 = 100.856, P <0.05), and the constituent ratio of EV71, Cox A16 and other enteroviruses was lower than that of non- 19.724, P <0.05; χ ~ 2 = 23.305, P <0.05; χ ~ 2 = 8.855, P <0.05). Conclusion Cox A6 has become the major pathogen of hand-foot-mouth disease in Baoding and is closely related to the dementia after hand-foot-mouth disease.