目的:通过对首例甲型H1N1流感密切接触者临床医学观察发现二代患者,为大规模临床医学观察积累经验和参考。方法:对首例甲型H1N1流感患者密切接触者115例的临床医学观察资料进行回顾性分析。结果:115例密切接触者中,有6人出现不同程度咽充血、咽部疼痛症状,其中1例为糖尿病患者、2例为高血压患者;1例左前臂疱疹,1例口腔溃疡,4例结膜充血;观察第3天1例出现精神抑郁,1例出现情绪激动;观察第4天2例多次要求提前解除隔离,多例关心何时解除隔离。七日医学观察期间115例密切接触者均无咽痛、咳嗽、鼻塞等症状,体温均正常,情绪稳定,未发现二代患者。结论:对甲型H1N1流感患者的密切接触者进行临床医学观察是必要的,有助于发现二代患者,疾控中心(CDC)采样与临床医学观察和心理干预的有效结合,给传染病医学观察提供宝贵的经验和有效的工作模式。 OBJECTIVE: Through the clinical observation of the first case of close contact with influenza A (H1N1), we found that the second generation of patients accumulated experience and reference for large-scale clinical observation. Methods: A retrospective analysis was performed on the clinical data of 115 cases of the first case of close contact with patients with influenza A (H1N1). Results: Of the 115 close contacts, 6 had pharyngeal congestion and pharyngeal pain in varying degrees. Among them, 1 was diabetic and 2 was hypertensive; 1 was left forearm herpes, 1 was oral ulcer and 4 was Conjunctival hyperemia was observed. On the third day, one case showed depression, and one case was emotionally excited. On the fourth day, two cases were asked to be released early and repeatedly, and many cases were concerned about when to release the isolation. During the seven-day medical observation, 115 cases of close contacts had no symptoms of sore throat, cough, stuffy nose, body temperature were normal, emotional stability, and found no second-generation patients. Conclusions: Clinical observation of close contacts in patients with Influenza A (H1N1) is necessary for the discovery of effective combination of second-generation CDC sampling with clinical medical observation and psychological intervention, Observation provides valuable experience and effective work patterns.