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一种活性药物要引起某种效应,必须经历3个主要过程:(1)药剂学过程,即从给药到药物溶解,使药物处于可吸收状态。(2)药代动力学过程,即药物的吸收、分布、代谢和排泄,使药物在血浆内产生一定的浓度,从而有可能达到作用部位发挥作用;(3)药效学过程,即药物以一定有效浓度进入作用部位并与机体某种成分相互作用,从而引起药物效应。近年来药代动力学研究取得了喜人的进展,本文仅就肾功能衰竭(简称肾衰)时药代动力学变化及其临床意义作一简要介绍。人们早已知道,大多数药物或其代谢产物主要经肾脏排泄,当肾功能衰退时容易导致蓄积中毒。近年来许多研究揭示:肾衰时药物在吸收、蛋白结
An active drug to cause some effect, must go through three main processes: (1) the pharmacy process, that is, from the administration to the drug dissolved, the drug is in a state of absorption. (2) pharmacokinetic process, that is, the absorption, distribution, metabolism and excretion of drugs, so that the drug produces a certain concentration in the plasma, which may reach the site of action; (3) pharmacodynamic process, that is, the drug Certain effective concentrations enter the site of action and interact with certain components of the body, causing a drug effect. In recent years, pharmacokinetic research has made gratifying progress, this article only on renal failure (referred to as renal failure) pharmacokinetic changes and its clinical significance of a brief introduction. It has long been known that most drugs or their metabolites are predominately excreted by the kidneys, causing accumulation poisoning when renal function declines. In recent years, many studies have revealed that drugs are absorbed during renal failure, protein junction