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目的探讨5种重金属Cr、Ni、Cu、Zn、Hg与女性乳腺癌发病的关系。方法 2010年11月-2011年5月采集43例乳腺癌患者及43例同期住院非乳腺癌、非内分泌疾病的对照患者的全血标本,采用电感耦合等离子体质谱仪(ICP-MS)进行Cr、Ni、Cu、Zn、Hg重金属含量测定。结果乳腺癌患者全血中Cr、Cu含量明显高于对照组(t值分别为2.104、1.834,P<0.05);Zn、Ni含量与对照组差异无统计学意义(t值分别为0.333、1.095,P>0.05);对照组全血中未检出Hg。消除流产次数混杂因素影响后,Cu高暴露组乳腺癌患病风险是低暴露组的4.625倍;消除是否使用杀虫剂混杂因素影响后,Cu高暴露组乳腺癌患病风险是低暴露组的6.531倍。结论重金属Cu的高暴露可能增加乳腺癌的发病风险。
Objective To investigate the relationship between five heavy metals (Cr, Ni, Cu, Zn, Hg) and the incidence of breast cancer in women. Methods From November 2010 to May 2011, blood samples of 43 patients with breast cancer and 43 patients with non-breast cancer and non-endocrine disease hospitalized in the same period were collected and analyzed by inductively coupled plasma mass spectrometry (ICP-MS) , Ni, Cu, Zn, Hg heavy metals content determination. Results The levels of Cr and Cu in whole blood of patients with breast cancer were significantly higher than those of the control group (t = 2.104 and 1.834, respectively, P <0.05). There were no significant differences in the contents of Zn and Ni between the two groups (t = 0.333 and 1.095 , P> 0.05); Hg was not detected in whole blood of the control group. After eliminating the miscellaneous factors, the risk of breast cancer in high Cu exposure group was 4.625 times higher than that in low exposure group. After eliminating the influence of mixed factors, the risk of breast cancer in high Cu exposure group was lower than that in low exposure group 6.531 times. Conclusion High exposure to heavy metal Cu may increase the risk of breast cancer.