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目的比较两种抗癫痫药物奥卡西平(OXC)和左乙拉西坦(LEV)治疗新诊断部分性发作患儿的临床疗效和安全性。方法选择于广东省珠海市人民医院神经内科就诊的100例新诊断部分性发作患儿作为研究对象,随机分为OXC和LEV两组各50例,OXC组给予奥卡西平片治疗,LEV组给予左乙拉西坦片治疗,观察并记录两组患者的发作例数和不良反应情况、治疗后作觉醒/睡眠脑电图记录。结果两组大部分患者完成全部疗程(48/50,49/50),在癫痫发作频率的下降和痫样放电减少方面,两组数据差异均不具统计学意义(P>0.05);不良反应方面,LEV组出现脾气暴躁等不良反应4例,OXC组出现头晕3例,嗜睡1例,认知功能减退4例。结论 OXC与LEV两种抗癫痫药物治疗新诊断部分性发作患儿疗效相似,但考虑到严重不良反应因素,LEV安全性更高,值得进一步临床推广。
Objective To compare the clinical efficacy and safety of two antiepileptic drugs oxcarbazepine (OXC) and levetiracetam (LEV) in newly diagnosed children with partial seizures. Methods A total of 100 newly diagnosed partial seizures in the Department of Neurology, People’s Hospital of Zhuhai, Guangdong Province were selected as study subjects. They were randomly divided into OXC and LEV groups of 50 cases each. OXC group received oxcarbazepine tablets and LEV group Levofloxacin treatment, observation and record of the two groups of patients the number of attacks and adverse reactions, after treatment for wake / sleep EEG records. Results The majority of patients in both groups completed the entire course of treatment (48 / 50,49 / 50). There was no significant difference between the two groups in the reduction of seizure frequency and epileptiform discharge (P> 0.05). Adverse reactions , 4 cases of adverse reactions such as temper and lentigo in LEV group, 3 cases of dizziness in OXC group, 1 case of drowsiness and 4 cases of cognitive decline. Conclusion Both OXC and LEV antiepileptic drugs have similar efficacy in the newly diagnosed partial seizures, but LEV is more safe given the serious adverse reactions and is worth further clinical promotion.