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目的:探讨联合应用DNA定量分析技术和宫颈液基细胞学检查在宫颈癌筛查中的应用价值。方法:对于1 264例宫颈癌筛查妇女分别进行DNA定量分析和宫颈液基细胞学检查,将筛查结果进行对比分析。结果:在得到随访结果的34例患者中,DNA定量分析检查的灵敏度为85.7%,高于宫颈液基细胞学检查的敏感度66.7%,两种检测方法的特异度相同。结论:DNA定量分析技术的敏感度高于宫颈液基细胞学检查,这种电脑辅助的自动化检查方法可以和宫颈液基细胞学检查联合运用于宫颈癌筛查中。
Objective: To investigate the value of DNA quantitative analysis combined with cervical liquid-based cytology in cervical cancer screening. Methods: For 1 264 cases of cervical cancer screening women were DNA quantitative analysis and cervical liquid-based cytology, the screening results were compared. RESULTS: Of the 34 patients who received the follow-up results, the sensitivity of the DNA quantification test was 85.7%, which was higher than that of the cervical liquid-based cytology test (66.7%). The specificity of the two tests was the same. CONCLUSIONS: The sensitivity of DNA quantification techniques is higher than that of cervical liquid-based cytology. This computer-assisted automated test can be used in conjunction with cervical-liquid-based cytology in cervical cancer screening.