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以金刚烷胺为起始反应物,首先在过量甲酸存在下,与甲醛发生埃斯韦勒-克拉克甲基化反应合成了N,N-二甲基金刚烷叔胺,在此基础上通过N,N-二甲基金刚烷叔胺与氯乙酸钠、溴代正丁烷、溴代正辛烷、溴代十二烷、溴代十六烷等一系列季铵化试剂的季铵化反应,分别合成了N,N-二甲基金刚烷甜菜碱型表面活性剂及N-(1-金刚烷基)-N,N-二甲基正丁基溴化铵、N-(1-金刚烷基)-N,N-二甲基辛基溴化铵、N-(1-金刚烷基)-N,N-二甲基十二烷基溴化铵、N-(1-金刚烷基)-N,N-二甲基十六烷基溴化铵等金刚烷季铵盐阳离子型表面活性剂,产率分别为75%,75%,61%,44%,54%.采用元素分析,IR,1H NMR等分析手段对5种产物进行了结构鉴定,测试了各种金刚烷表面活性剂水溶液的表面张力.
Amantadine as the starting reactant, first in the presence of excess formic acid, Ester-Clarke methylation reaction with formaldehyde synthesized N, N-dimethyl adamantane tertiary amine, on this basis through the N , Quaternization reaction of N-dimethyladamantane tertiary amine with a series of quaternization reagents such as sodium chloroacetate, n-butyl bromide, n-octyl bromide, bromododecane, and bromohexadecane , N, N-dimethyl adamantane betaine surfactants and N- (1-adamantyl) -N, N-dimethyl n-butylammonium bromide, N- Alkyl) -N, N-dimethyloctylammonium bromide, N- (1-adamantyl) -N, N- dimethyldodecyl ammonium bromide, N- (1-adamantyl ) -N, N-dimethyl cetylammonium bromide and other adamantane quaternary ammonium salt cationic surfactants, the yields were 75%, 75%, 61%, 44%, 54%, respectively. , IR, 1H NMR and other analytical means to identify the structure of five products, tested a variety of adamantane surfactant aqueous solution of the surface tension.