目的观察EP方案治疗小细胞肺癌的临床疗效和毒副作用。方法EP方案:鬼臼乙叉甙100 mg/iv d1-3,顺铂80 mg/iv d1,对56例小细胞肺癌进行化疗,21～28d为1个周期,连续2个周期后复查,评价疗效。结果完全缓解率为10%,总有效率达到91%,无效5%,毒副反应轻中度骨髓抑制及消化道反应,经过相应支持对症治疗缓解,经水化治疗未出现肾毒性反应。结论EP方案治疗小细胞肺癌疗效肯定,各期小细胞肺癌无禁忌征者均可选择。 Objective To observe the clinical efficacy and side effects of EP regimen in the treatment of small cell lung cancer. Methods EP regimen: etoposide 100 mg / iv d1-3, cisplatin 80 mg / iv d1, 56 cases of small cell lung cancer chemotherapy, 21 ~ 28d for a cycle, two consecutive cycles after the review, evaluation Efficacy. Results The complete remission rate was 10%, the total effective rate was 91%, and 5% was ineffective. The mild and moderate myelosuppression and digestive tract toxicity were relieved. The symptomatic treatment was relieved with the corresponding support, and no nephrotoxic response was found after hydration therapy. Conclusion The EP regimen is effective in treating small cell lung cancer, and no contraindication for small cell lung cancer is available at each stage.