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目的:探讨妊娠期高血压疾病患者血清甲胎蛋白(AFP)水平对围产儿预后的影响。方法:采用放射免疫法测定118例孕中期妊娠期高血压疾病患者血清甲胎蛋白值,根据其AFP值分为观察组1(≥250μg/L)54例和观察组2(<250μg/L)64例;测定同期160例正常妊娠孕妇(对照组)的血清AFP水平。所有孕妇均随访至分娩。结果:观察组1的足月小样儿发生率、新生儿出生1分钟Apgar评分≤7分者百分率、S/D异常发生率、新生儿窒息发生率及围生儿死亡率均高于观察组2,差异有统计学意义(P<0.05)。结论:孕妇血清AFP水平异常升高影响围生儿预后,产前监测血清AFP值有一定的临床意义。
Objective: To investigate the effect of serum alpha-fetoprotein (AFP) level on the prognosis of perinatal infants in patients with gestational hypertension. Methods: The serum alpha-fetoprotein values of 118 pregnant women with gestational hypertension during pregnancy were determined by radioimmunoassay. According to their AFP values, 54 cases of observation group 1 (≥ 250μg / L) and 2 cases of observation group 2 (<250μg / L) 64 cases; Determination of the same period 160 cases of normal pregnant women (control group) serum AFP levels. All pregnant women were followed until delivery. Results: The incidence of full-term small sample in observation group 1, the percentage of Apgar score less than 7 points, the incidence of S / D abnormalities, neonatal asphyxia and perinatal mortality at 1 minute after birth were all higher than those in observation group 2 , The difference was statistically significant (P <0.05). Conclusion: The abnormal serum AFP levels in pregnant women affect the prognosis of perinatal children. Prenatal monitoring serum AFP value has certain clinical significance.