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目的探讨中西医结合治疗食管癌术后反流性食管炎(RE)患者的临床疗效。方法选取2012年5月至2016年5月锦州市中医医院收治的食管癌术后出现RE患者78例为研究对象,按随机数字表法分为对照组和观察组,每组39例。对照组患者采用常规西医治疗,观察组患者采用中西医结合治疗。比较两组患者治疗后的临床疗效、症状缓解时间、复发率、不良反应发生率及生命质量,以及两组患者治疗前后食管24 h p H检测结果。结果观察组患者的治疗总有效率为97.4%,明显高于对照组的74.4%,差异有统计学意义(P<0.01);观察组患者的症状缓解时间较对照组缩短,复发率和不良反应发生率均低于对照组,差异均有统计学意义(均P<0.01);治疗后两组患者精神状况及躯体健康评分均明显高于治疗前,且观察组明显高于对照组,差异均有统计学意义(均P<0.01);与治疗前比较,两组患者治疗后食管24 h p H检测各项指标均有所下降,差异均有统计学意义(均P<0.01),且观察组下降更为明显,组间差异有统计学意义(P<0.01)。结论中西医结合治疗食管癌术后RE可以提高抑酸效果,缩短症状缓解时间,降低复发率,提高患者治疗后的生命质量。
Objective To explore the clinical efficacy of integrated traditional Chinese and western medicine in the treatment of postoperative esophageal reflux esophagitis (RE) in patients with esophageal cancer. Methods From May 2012 to May 2016, 78 cases of RE patients who underwent esophagectomy after operation in Jinzhou Chinese Medicine Hospital were enrolled in this study. According to the random number table, they were divided into control group and observation group, 39 cases in each group. The control group of patients treated with conventional Western medicine, observation group of patients with Integrative Medicine. The clinical curative effect, symptom relief time, relapse rate, incidence of adverse reactions and quality of life were compared between the two groups after treatment, and the esophageal 24 h p H test results were compared between the two groups before and after treatment. Results The total effective rate of observation group was 97.4%, which was significantly higher than that of control group (74.4%), the difference was statistically significant (P <0.01); the symptom relief time of observation group was shorter than that of control group, the recurrence rate and adverse reactions (P <0.01). After treatment, the mental status and physical health scores of the two groups were significantly higher than those before treatment, and the observation group was significantly higher than the control group, the difference was statistically significant (All P <0.01). Compared with those before treatment, the indexes of 24 hp in esophageal decreased after treatment in both groups (all P <0.01), and the observation group The decline was more obvious, the difference between groups was statistically significant (P <0.01). Conclusion Integrative treatment of esophageal cancer after RE can improve the acid suppression effect, shorten the time to relieve symptoms, reduce the recurrence rate and improve the quality of life of patients after treatment.