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Latt等(1973)首次报道了在人类淋巴细胞培养物中X染色体的DNA复制与某些特定染色体区域之间有精确的相关。他们用5-溴脱氧尿苷(BrdU)掺入染色体DNA中,经荧光染料(Hoechst 33258)作用和Giemsa复染,使中期染色体的早或晚
Latt et al. (1973) reported for the first time that there was an exact correlation between DNA replication of the X chromosome in human lymphocyte cultures and certain specific chromosomal regions. They incorporate 5-bromodeoxyuridine (BrdU) into the chromosomal DNA and counterstain them with Giemsa via the fluorescent dye (Hoechst 33258) to make early or late metaphase chromosomes