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观察辅酶Ｑ１０对心肌缺血再灌注损伤的保护作用，随机选择２０例拟行体外循环心内直视手术的患儿分为Ａ组：辅酶Ｑ１０组，Ｂ组：对照组，各１０例。在术前６天、术晨、阻断升主动脉前５分钟、开升主钳后１５分钟和３０分钟，术后第１天和第４天的７个时点抽取股静脉血测丙二醛、磷酸肌酸激酶同工酶、α－羟丁酸脱氢酶和内源性超氧化物歧化酶的血清浓度。结果：心肌缺血再灌注后血清丙二醛、磷酸肌酸激酶同工酶、α－羟丁酸脱氢酶浓度均显著增加，而内源性超氧化物歧化酶浓度显著下降，术后变化也很显著，两组间各时点术后变化有显著差异，Ａ组变化较Ｂ组轻，恢复也较快。说明氧自由基对心肌缺血再灌注损伤的作用至少可持续到术后３天或更长时间，辅酶Ｑ１０对减轻氧自由基的损害非常有效，应从整个围术期考虑应用。
To observe the protective effect of coenzyme Q10 on myocardial ischemia-reperfusion injury, randomly selected 20 cases of children undergoing open heart surgery undergoing cardiopulmonary bypass were divided into group A: coenzyme Q10 group, group B: control group, each 10 cases. 6 days before surgery, morning surgery, blocking the ascending aorta 5 minutes before opening the main forceps after 15 minutes and 30 minutes after the first day and the fourth day of the 7 points of time to take femoral vein blood test C Aldehyde, creatine kinase creatine kinase isozyme, alpha-hydroxybutyrate dehydrogenase, and endogenous superoxide dismutase. Results: Serum malondialdehyde, creatine phosphokinase and α-hydroxybutyrate dehydrogenase concentrations were significantly increased after myocardial ischemia and reperfusion, while the concentration of endogenous superoxide dismutase was significantly decreased and the postoperative changes Is also significant, between the two groups at different time points postoperative changes were significantly different, A group of changes than the B group lighter, faster recovery. That oxygen free radicals on myocardial ischemia-reperfusion injury can be sustained at least 3 days or more after the coenzyme Q10 to reduce the damage of oxygen free radicals is very effective, should be considered from the perioperative application.