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以红霉素发酵液为对象设计实验，考查内压式中空纤维的膜通量衰减现象。其衰减的主要原因是膜表面吸附蛋白质以及在膜表面形成浓差极化层。保留液浓度影响膜通量是间接的，其外在宏观表现为保留液浓度高、膜的处理量大和处理时间长都将加剧膜通量衰减。在实际应用中须考虑这些因素
Erythromycin fermentation broth was used as an experimental design to examine the attenuation of membrane flux in hollow fiber. The main reason for its attenuation is the adsorption of proteins on the membrane surface and the formation of a concentration polarization layer on the membrane surface. The effect of retention solution concentration on membrane flux is indirect, and its macroscopic external appearance is high concentration of retention solution, large membrane treatment volume and long treatment time will aggravate membrane flux decay. In practical applications must consider these factors