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心得安临床应用将有20年,是抗高血压、心律失常和心绞痛的常用药。近年对其认识和应用又有较大进展,现概要复习如下: 效应的新认识一、对心血管的作用,(一)阻滞β_1受体作用,拮抗过高的交感神经张力。降慢心肌舒张期去极化、延长不应期。使心肌收缩力减弱、心率减少、传导减慢、自律性降低。结果心脏负荷减轻,心排出量降低。约可减少心肌耗氧量25%。(二)使冠状动脉血液重新流向缺血区,促使氧合血红蛋白分离曲线右移,改善缺血心肌的氧供。(三)抗血小板聚集,降低全血粘度。其机理一方面阻断儿茶酚胺类物质的释放因而降低血
Adventurous clinical application will have 20 years, is anti-hypertension, arrhythmia and angina commonly used drugs. In recent years, their understanding and application of great progress, the summary review is as follows: a new understanding of the effect of a cardiovascular effect, (a) block β1 receptor, antagonism of excessive sympathetic tone. Decreased myocardial diastolic depolarization, prolonged refractory period. So that myocardial contractility weakened, reduced heart rate, conduction slowed, reduced self-discipline. As a result, cardiac load was reduced and cardiac output was reduced. Reduce myocardial oxygen consumption about 25%. (B) to re-flow of coronary blood flow to the ischemic area, prompting the oxyhemoglobin separation curve to the right, to improve myocardial oxygen supply. (C) anti-platelet aggregation, reduce whole blood viscosity. On the one hand, its mechanism blocks the release of catecholamines and thus reduces blood