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1988年研究人员在研究低氧和低氧诱导的促红细胞生成素(EPO)基因表时发现了低氧对基因表达的作用[1],随后于1995年Wang等[2-3]和Semenza等[4]发现了缺氧诱导因子1(hypoxia-inducible factor-1,HIF-1)转录因子和低氧反应元件(HRE)。大量研究表明,恶性肿瘤的发生、发展是一个十分复杂的过程,是细胞生长与增
In 1988, researchers found hypoxia effects on hypoxia and hypoxia-induced erythropoietin (EPO) gene expression [1], followed by Wang et al. [2-3] and Semenza et al [4] found hypoxia-inducible factor-1 (HIF-1) transcription factor and hypoxia response element (HRE). A large number of studies have shown that the occurrence and development of malignant tumors is a very complicated process, which is the cell growth and proliferation