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P1938-1947在转基因小鼠中自发生成的传染性朊病毒病//Juan-María Torres,Joaquín Castilla,等我们在转基因小鼠身上表达113位密码子为亮氨酸(113L突变)的牛朊病毒蛋白(PrPC)。该蛋白质与102L突变的人蛋白质同源,102L突变已证实与GSS有遗传学的联系。这种PrPC突变可导致完全渗透的、致命的海绵状脑病。该遗传疾病可通过
P1938-1947 Infectious Prion Disease Spontaneous in Transgenic Mice // Juan-María Torres, Joaquín Castilla, et al. We expressed 113 prions of leucine (113L mutation) in the transgenic mice Protein (PrPC). This protein is homologous to the 102L mutant human protein and the 102L mutation has been shown to be genetically linked to GSS. This PrPC mutation can result in a fully penetrating, deadly spongiform encephalopathy. The genetic disease can be passed