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目的研究对存在呼吸衰竭的慢性阻塞性肺疾病老年患者采用无创通气联合沙美特罗替卡松气雾剂(舒利迭)治疗对患者肺部功能以及动脉血气改善效果。方法呼吸衰竭的慢性阻塞性肺疾病老年患者70例,随机分为对照组及观察组,每组35例。对照组在常规基础上采用无创通气治疗,观察组另加用舒利迭药物。对比两组患者一秒用力呼气容积(FEV1)、一秒用力呼气容积占用力肺活量比值(FEV1/FVC)以及一秒用力呼气容积占预计值百分数(FEV1%)预计值以及p H值、血氧分压(Pa O2)以及二氧化碳分压(Pa CO2)情况。结果观察组在治疗后各检测项目改善程度均优于对照组,治疗后组间对比差异具有统计学意义(P<0.05)。结论在常规治疗基础上采用无创通气联合舒利迭药物治疗方式治疗呼吸衰竭慢性阻塞性肺疾病患者可达到更好的治疗效果,具有临床推广价值。
Objective To investigate the effects of non-invasive ventilation combined with salmeterol and fluticasone-aerosol (seretide) on lung function and arterial blood gas in elderly patients with chronic obstructive pulmonary disease with respiratory failure. Methods Seventy elderly patients with chronic obstructive pulmonary disease of respiratory failure were randomly divided into control group and observation group with 35 cases in each group. In the control group, noninvasive ventilation was used on the routine basis. The observation group was additionally treated with seretide. The FEV1, FEV1 / FVC and FEV1% predictive values and p H values were compared between the two groups , Partial pressure of oxygen (Pa O2) and partial pressure of carbon dioxide (Pa CO2). Results After treatment, the observation group improved more than the control group after treatment. The difference between the two groups after treatment was statistically significant (P <0.05). Conclusion Noninvasive ventilation combined with seretide can improve the therapeutic effect in patients with chronic obstructive pulmonary disease due to respiratory failure, which has the clinical value of popularization.