Sedimentation of particles in inclined and vertical vessels is numerically simulated by the Eulerian two-fluid model. The numerical results show an interesting phenomenon with two circulation vortexes in a vertical vessel but one in the inclined vessel. Sensitivity tests indicate that the boundary layer effect is the key to induce this phenomenon. A numerical method based on 2D unstructured meshes is presented to solve the hard-sphere discrete particle model. Several applications show the numerical method has a good performance to simulate dense particulate flows in irregular domains without regard to element types of the mesh.