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探讨Ｐ┐选择素表达与ＳＣＩＤ小鼠人胃癌原位移植瘤的转移关系。方法ＲＴ┐ＰＣＲ检测正常胃组织及移植瘤模型胃癌组织中的Ｐ┐选择素表达。结果Ｐ┐选择素在正常胃组织及胃癌组织均有不同程度的表达，８０％淋巴结有癌转移的胃癌组织中的Ｐ┐选择素表达强于正常及２０％淋巴结转移阴性的胃癌组织，表达强度与转移率呈明显的正相关（Ｐ＜０．０１）。结论选择素可能在胃癌转移中起重要作用。
To investigate the relationship between the expression of P┐-selectin and the orthotopic transplanted human gastric carcinoma in SCID mice. Methods RT-PCR was used to detect the expression of P┐-selectin in normal gastric tissue and xenograft model gastric cancer tissue. Results The expression of P┐selectin in normal gastric tissue and gastric cancer tissues was different. The expression of P┐selectin in gastric cancer tissues with 80% lymph node metastasis was stronger than that in normal gastric cancer tissues with 20% negative lymph node metastasis. There was a significant positive correlation with metastasis rate (P<0.01). Conclusion Selectins may play an important role in the metastasis of gastric cancer.