许多不同的癌基因,血清生长因子和肿瘤促进剂TPA对转录的激活都要AP-1和PEA3的协同作用。本文作者证明以前不知其功能的原璃基因ets-1和ets-2的产物是一类通过PEA3结合区激活转录的转录因子。p68 蛋白特异性地同DNA结合,并含有转录激活结构域。这个结构域同其它转录因 Many different oncogenes, serum growth factors and tumor promoter TPA have a synergistic effect on the transcriptional activation of AP-1 and PEA3. The authors demonstrate that the products of the previously unknown ets-1 and ets-2 motifs of the vitronectin are a class of transcription factors that activate transcription through the PEA3 binding domain. The p68 protein specifically binds to DNA and contains a transcriptional activation domain. This domain is related to other transcription factors