【摘 要】
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Lipid peroxide (LPO) plays pivotal roles in the process and development of many diseases. In this work, we studied the in-hibitory effect of probimane (Pro), a
【机 构】
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School of Life Sciences, Shanghai University, Shanghai 200436, ChinaShanghai Institute of Materia Me
论文部分内容阅读
Lipid peroxide (LPO) plays pivotal roles in the process and development of many diseases. In this work, we studied the in-hibitory effect of probimane (Pro), a Chinese anticancer agent, on erythrocyte LPO and the interaction of Pro with sialic acids (sia).Malondialdehyde (MDA) of erythrocytes activated by hydrogen peroxide was measured. Pro was found to inhibit the product of LPOinduced by hydrogen peroxide in a non-enzyme system of both rabbit and human erythrocytes in the absence of doxorubicin. Sia werefound to enhance LPO production and the activity of N-glycolylneuraminic acid (NeuGc) was about 5 times higher than that of N-acetylneuraminic acid (5AcNeu) at equivalent concentrations. Pro inhibited the increased LPO production induced by sia and the activ-ity of Pro against LPO with 5AcNeu was almost twofold higher than that of Pro alone. It suggests that Pro be an inhibitor of LPO (freeradicals) and as a functional modulator of sia in body.
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