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本文应用CD_3、CD_4、CD_8单克隆抗体酶标试剂检测44例慢性丙型病毒性肝炎(慢丙肝)患者外周血T淋巴细胞亚群,其结果与20例正常人比较,显示CD_3、CD_4、CD_4/CD_8比值明显降低,CD_8则明显升高;其中34例慢丙肝接受了国产基因工程干扰素α_1治疗,治疗前后CD_3、CD_4、CD_8、CD_4/CD_8比值与10例对照组比较均无明显差异。研究结果表明,慢丙肝体内存在T淋巴细胞比例失衡;国产基因工程干扰素α_1对调节细胞免疫功能不理想。
In this paper, 44 cases of chronic hepatitis C (chronic hepatitis C) patients with peripheral blood T lymphocyte subsets were detected by CD_3, CD_4, CD_8 monoclonal antibody enzyme-labeled reagent, and the results were compared with 20 normal subjects, showing CD_3, CD_4, CD_4 / CD_8 ratio decreased significantly and CD_8 increased significantly. Among them, 34 cases of chronic hepatitis C received domestic-made interferon alfa-1 treatment. There was no significant difference in the ratio of CD_3, CD_4, CD_8 and CD_4 / CD_8 before and after treatment compared with 10 control subjects. The results show that the presence of T lymphocytes in chronic hepatitis B imbalance; domestic genetic engineering interferon alpha 1 to regulate cellular immune function is not ideal.