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目的 观察４ 种广谱抗生素对小鼠急性弓形虫病的治疗效果。方法 弓形虫ＲＨ株速殖子腹腔感染小鼠，分别用氧氟沙星、环丙沙星、克林霉素、美浓霉素以及克林霉素、美浓霉素与乙胺嘧啶联合应用进行治疗，以磺胺嘧啶加乙胺嘧啶及不治疗作为对照，观察小鼠的死亡时间，４ 周后存活鼠盲传一代，仍不发病者为治愈。结果 单独使用效果均不理想；克林霉素、美浓霉素与乙胺嘧啶联合使用１０ 天，可杀灭弓形虫，使小鼠痊愈。结论 克林霉素、美浓霉素与乙胺嘧啶联用为良好的急性弓形虫病治疗药物。
Objective To observe the therapeutic effects of four kinds of broad-spectrum antibiotics on acute toxoplasmosis in mice. Methods Toxoplasma gondii RH strain tachyzoites were intraperitoneally infected with ofloxacin, ciprofloxacin, clindamycin, minocycline, and clindamycin, meloxicam and pyrimethamine in combination Treatment, with sulfadiazine plus pyrimethamine and no treatment as a control, observe the time of death in mice, 4 weeks after the survival of mice blind pass the generation, still not the disease were cured. The results alone were not satisfactory results; clindamycin, mercapto and pyrimethamine combined use of 10 days to kill Toxoplasma gondii, the mice recovered. Conclusions Clindamycin, meloxicam and pyrimethamine are good therapeutic agents for acute toxoplasmosis.