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心室收缩末期压力容积关系和压力直径关系(ESPVR和ESPDR),是评定心室收缩能力的较好指标。本工作记录13只麻醉开胸狗左室内压,并用超声晶体植入法记录左室前后径。将阻截下腔静脉回流(IVC)降低前负荷以及狭缩胸主动脉(AO)增加后负荷两种情况下所获得的一系列连续心跳的收缩末期压力(Pes)和直径(Des),经最小二乘法求得IVC和AO时的ESPDR。结果表明:(1) IVC或AO情况下获得的Pes与Des均高度线性相关(r值分别为0.9505±0.0578和0.9298±0.0581,P均<0.001);(2) 注入多巴酚丁胺(dob)后,IVC和AO时的ESPDR直径轴截距(Do)均无改变,斜率(E_(max))则明显增大,且IVC时的增加(174.4±23.5％)大于AO时(78.7±22.6％);(3) 对照和dob两种情况下,AO时ESPDR的D_0均小于IVC时。提示麻醉开胸狗左室ESPDR的斜率对变力状态的变化敏感,但其敏感性以及ESPDR的直径轴截距受获得ESPDR所采用的改变负荷的方式的影响,其原因可能是不同方式改变负荷时引起的Pes和Ves变动范围有所不同的缘故。
The relationship between end-systolic pressure volume and pressure diameter (ESPVR and ESPDR) is a good indicator of ventricular systolic function. This work records 13 anesthetized thoracotomy left ventricular pressure, and use of ultrasonic crystal implantation method to record left ventricular anteroposterior diameter. The Pes and Diameter (Pes) and Diameter (Des) of a series of consecutive beats of interictal heartbeat obtained under both IVC-reduced preload and augmented-loaded aortic constriction (AO) ESPR for Quadrature IVC and AO. The results showed that: (1) Pes and Des were highly linear correlated with IVC or AO (r = 0.9505 ± 0.0578 and 0.9298 ± 0.0581, respectively, P <0.001); (2) injection of dobutamine The ESPDR diameter axis intercept (Do) did not change and the slope (E max) increased significantly at IVC and AO, and the increase of IVC (174.4 ± 23.5%) was greater than that of AO (78.7 ± 22.6 %); (3) In both cases of control and dob, the D_0 of ESPDR in AO is less than IVC. It is suggested that the slope of the left ventricular ESPDR in anesthetized open-chest dogs is sensitive to the change of state of force, but the sensitivity and the ESP ESP’s diameter-axis intercept are affected by the way to change the load used to obtain ESPDR, which may be due to different ways to change the load Pes and Ves caused by changes in the scope of the different reasons.