论文部分内容阅读
目的:观察中西医结合治疗小儿原发性肾病综合征(PNS)的临床疗效。方法:将67例PNS患儿随机分为治疗组34例、对照组33例。均给予激素及免疫抑制剂、抗凝、钙剂等西药对症治疗,治疗组在此基础上加用中医药辨证施治。治疗前后分别检测血清甘油三酯(TG)、胆固醇(TC)、血肌酐、血黏度、血小板聚集率、24h尿蛋白定量。结果:治疗组完全、基本、部分缓解率及无效率,与对照组比较,差异有显著性意义(P<0.05)。所有入选病例随访1～5年,治疗组复发率也低于对照组,2组比较,差异有显著性意义(P<0.05)。2组治疗后TG、TC、血黏度、血小板聚集率、24h蛋白尿定量均明显下降,与治疗前比较,差异有显著性意义(P<0.05)。治疗组下降更为显著,与对照组比较,差异有显著性意义(P<0.05)。结论:中西医结合治疗小儿PNS疗效确切,较之单纯西药治疗有明显优势。
Objective: To observe the clinical efficacy of integrated traditional Chinese and western medicine in treating children with primary nephrotic syndrome (PNS). Methods: Sixty-seven children with PNS were randomly divided into treatment group (34 cases) and control group (33 cases). All were given hormones and immunosuppressive agents, anticoagulants, calcium and other Western symptomatic treatment, the treatment group based on the use of traditional Chinese medicine syndrome differentiation. Before and after treatment, serum triglyceride (TG), cholesterol (TC), serum creatinine, blood viscosity, platelet aggregation rate, 24h urinary protein were measured. Results: The treatment group was complete, basic, partial response rate and inefficiency, compared with the control group, the difference was significant (P <0.05). All cases were followed up for 1 to 5 years, and the recurrence rate in the treatment group was also lower than that in the control group. There was significant difference between the two groups (P <0.05). After treatment, TG, TC, blood viscosity, platelet aggregation rate and proteinuria in 24 hours were significantly decreased in both groups. There was significant difference between before and after treatment (P <0.05). The treatment group decreased more significantly, compared with the control group, the difference was significant (P <0.05). Conclusion: The combination of TCM and Western medicine treatment of pediatric PNS exact effect, compared with Western medicine alone has obvious advantages.