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毒扁豆碱是一种对抗胆碱能谵妄综合征有诊断和治疗价值的抗胆碱酶制剂;作者用毒扁豆碱持续静脉输入治愈1例过量服用苯甲托品与阿米替林导致的中毒性抗胆碱能谵妄状态。在患者服药6小时急诊入院,在52小时内共用毒扁豆碱77毫克,病情逐渐恢复。有选择性的静脉输入毒扁豆碱,可获安全可靠的独特疗效。但使用中须注意中毒反应,本药有胆碱能兴奋作用,故坏疽、哮喘、溃疡性结肠炎、肠梗阻与心血管病等慎用。
Physostigmine is an anticholinergic agent against the diagnosis and treatment of cholinergic delirium syndrome; the authors treated with intravenous injection of physostigmine for 1 case of overdose of atropine and amitriptyline Toxic anticholinergic delirium state. In patients taking 6 hours emergency admission, sharing physostigmine 77 mg within 52 hours, the condition gradually recovered. A selective intravenous physostigmine can be uniquely safe and reliable. However, use should pay attention to toxic reactions, the drug has cholinergic excitement, so gangrene, asthma, ulcerative colitis, intestinal obstruction and cardiovascular disease with caution.