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目的:在以往研究的基础上,进一步探讨肾虚肝郁型早期先兆流产时血清CA125的变化与妊娠结局的关系。方法:选择肾虚肝郁型早期先兆流产患者142例,随机分为中药治疗组72例和黄体酮对照组70例。动态观察两组治疗前后血清CA125水平的变化,并随访妊娠结局。结果:治疗组保胎成功率为81.94%,对照组78.57%,两组比较经统计分析无显著性差异。疗后两组患者血清CA125水平呈下降趋势,治疗组中治疗前后相比有显著性差异;组间各时段差异无统计学意义。但保胎成功组和失败组治疗前后各时段血清CA125水平无显著性差异﹙P>0.05﹚。结论:滋肾柔肝法治疗肾虚肝郁型早期先兆流产疗效显著。对孕妇血清CA125动态监测结果提示:本研究结果尚不能证实“孕妇早期血清CA125水平可以评估妊娠最终结局”的观点。
OBJECTIVE: To further explore the relationship between the change of serum CA125 and the pregnancy outcome in the early stage of threatened abortion with kidney deficiency and liver depression based on the previous studies. Methods: 142 cases of early threatened abortion with deficiency of kidney and liver depression were randomly divided into two groups, 72 cases in traditional Chinese medicine group and 70 cases in progesterone control group. The changes of serum CA125 level before and after treatment were observed dynamically, and the pregnancy outcome was followed up. Results: The success rate of miscarriage in treatment group was 81.94% and in control group 78.57%. There was no significant difference between the two groups by statistical analysis. After treatment, serum CA125 levels in both groups showed a decreasing trend, and there was significant difference between the two groups before and after treatment. There was no significant difference between groups in each time period. However, there was no significant difference in serum CA125 levels between the failed fetus group and the failed group before and after treatment (P> 0.05). Conclusion: The method of nourishing the kidney and strengthening the liver to treat kidney deficiency and liver depression is effective in early threatened abortion. Dynamic monitoring results of serum CA125 for pregnant women suggest that the results of this study are not yet confirmed “early pregnancy serum CA125 levels can assess the final outcome of pregnancy ” point of view.