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10名正常妊娠妇女在择期性剖腹产术前口服氨茶碱200mg 每6小时一次共24～36小时。测定母体及脐带血清及羊水中氨茶碱及咖啡因的水平。氨茶碱水平在母体血清是10.4±1.74μg/ml,脐带血清是11.2±1.25μg/ml。血清氨茶碱水平在治疗范围内。咖啡因在这些标本中水平的范围是从微量至6μg/ml,在正常饮食摄取范围内。氨茶碱经常用以缓解患有支气管哮喘孕妇的发作。妊娠中哮喘的患病率是0.2～0.8‰。妊娠中使用氨茶碱时,有关药物在胎盘转运的知识报导很少。
10 normal pregnant women oral aminophylline 200mg once every 6 hours before elective caesarean section for a total of 24 to 36 hours. Determination of maternal and umbilical cord serum and amniotic fluid and amniotic fluid levels of caffeine. The aminophylline level was 10.4 ± 1.74 μg / ml in maternal serum and 11.2 ± 1.25 μg / ml in cord serum. Serum aminophylline levels within the treatment. The level of caffeine in these specimens ranged from trace to 6 μg / ml, within normal dietary intakes. Aminophylline is often used to relieve the onset of bronchial asthma in pregnant women. The prevalence of asthma during pregnancy is 0.2 ~ 0.8 ‰. When aminophylline is used during pregnancy, little is known about the drug’s transport in the placenta.