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本文目的旨在评价精子顶体蛋白酶抑制剂EGB栓的体内杀精子效果和抗生育作用。体内杀精实验结果表明,给予EGB栓25mg和50mg在家兔交配后5～20分钟,阴道内均未发现有活动精子。家兔抗生育实验结果表明,EGB栓12.5的避孕率为80%(P<0.001),25mg和50mg给药组的避孕率均为100％,与壬苯醇醚对照组的实验结果相同,与自然对照组和基质对照组相比有非常显著差异(P<0.001)。本文结果提示EGB栓具有体内杀精效果和抗生育作用。
The purpose of this paper is to evaluate the in vivo spermicidal effect and anti-fertility effects of the sperm acrosin inhibitor EGB suppository. In vivo spermicidal test results showed that given EGB suppository 25mg and 50mg 5 to 20 minutes after mating in rabbits, no intra-vaginal motility sperm were found. The results of anti-fertility experiments in rabbits showed that the contraceptive rate of EGB with 12.5 was 80% (P <0.001), and the contraceptive rates of both 25mg and 50mg groups were 100%, which were the same as that of nonoxynol control group There was a significant difference between the control group and the control group (P <0.001). Our results suggest that EGB suppository has in vivo spermicidal effect and anti-fertility effects.