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人破骨细胞生成抑制因子（ｏｓｔｅｏｃｌａｓｔｏｇｅｎｅｓｉｓ ｉｎｈｉｂｉｔｏｒｙｆａｃｔｏｒ，ＯＣＩＦ）或骨保护素（ｏｓｔｅｏｐｒｏｔｅｇｅｎｉｎ，ＯＰＧ），是在１９９７年，分别由两个不同的研究小组通过纯化人胚胎肺纤维母细胞ＩＭＲ－９０条件培养基和测序胎
Human osteoclastogenesis inhibitory factor (OCIF) or osteoprotegenin (OPG), was purified in two different groups by IMR-90 conditioned medium from human embryonic lung fibroblasts in 1997 And sequencing fetal