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研究蟾乌口腔粘膜表面麻醉剂的急性毒理为临床应用提供依据。用不同浓度的蟾乌口腔粘膜表面麻醉剂给实验性小鼠灌胃 ,采用改进寇氏法测定小鼠灌胃给药半数致死量(LD50 )。结果 蟾乌口腔粘膜表面麻醉剂半数致死量 (LD50 )为 (38 4 4± 3 16 )g kg-1。结论 蟾乌口腔粘膜表面麻醉剂动物实验结果显示对小鼠灌胃给药的急性毒性较小 ,有效浓度在临床中使用是安全的
To study the acute toxicology of surface anaesthetics of oral mucosa of Rhizoma Umbilicaria provides the basis for clinical application. The experimental mice were intragastrically administered with different concentrations of urine oral mucosal surface anesthetic, and the improved method was used to determine the median lethal dose (LD50). Results The median lethal dose (LD50) of topical anesthetic in oral mucosa of Rhizoma typhus was (38 4 4± 3 16 )g kg-1. Conclusion The experimental results of oral anaesthetics on oral mucous membranes of E. urticae show that the acute toxicity to oral administration of mice is relatively small, and the effective concentration is safe to use in clinical practice.