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目的通过观察不同水砷剂量慢性砷暴露昆明种雌鼠血清激素雌二醇、孕酮水平的变化,探讨砷的雌激素样效应。方法选择暴露于不同剂量As2O3(0、0.05、0.10、0.20和0.40μg/ml)饮水20周的昆明种雌鼠为研究对象,采用放射免疫法测定血清激素雌二醇与孕酮含量。结果慢性砷暴露雌鼠血清雌二醇和孕酮含量均有变化:与对照组比较,0.20μg/ml组(P<0.01)与0.40μg/ml组(P<0.05)雌二醇含量降低,0.10μg/ml组孕酮含量减少(P<0.01)。结论慢性砷暴露扰乱血清激素水平,砷具有雌激素效应。
Objective To observe the estrogen-like effects of arsenic by observing the changes of serum estradiol and progesterone levels in female rats exposed to chronic arsenic exposure to different doses of arsenic. Methods Kunming female rats exposed to different doses of As2O3 (0, 0.05, 0.10, 0.20 and 0.40 μg / ml) for 20 weeks were selected as the study objects. Serum estradiol and progesterone levels were determined by radioimmunoassay. Results The levels of serum estradiol and progesterone were all changed in chronic arsenic exposed women. Compared with the control group, the estradiol levels of 0.20μg / ml group and 0.40μg / ml group decreased (P <0.05) The progesterone level in the μg / ml group decreased (P <0.01). Conclusion Chronic arsenic exposure disrupts serum hormone levels and arsenic has estrogenic effects.