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目的:探讨苦碟子注射液辅助治疗对2型糖尿病伴周围神经病变患者微循环影响及安全性。方法:收集我院80例2型糖尿病伴周围神经病变患者,随机分为实验组和对照组,每组40例。对照组患者给予甲钴胺治疗,实验组患者给予苦碟子注射液治疗。观察并比较两组患者治疗前后微循环水平、周围神经评分、不良反应发生率及治疗效果。结果:与治疗前相比,治疗后两组患者管袢形态、管袢流态、袢周状态以及周围神经评分水平较低,差异具有统计学意义(P<0.05);与对照组相比,实验组患者治疗管袢形态、管袢流态、袢周状态以及周围神经评分水平较低,差异具有统计学意义(P<0.05);实验组并发症的发生率低于对照组,而临床治疗有效率高于对照组,差异均具有统计学意义(P<0.05)。结论:苦碟子注射液辅助治疗能够改善患者的微循环以及周围神经情况,临床疗效较好,安全性高。
Objective: To investigate the effect and safety of Kudiezi injection on microcirculation in patients with type 2 diabetes mellitus and peripheral neuropathy. Methods: Eighty patients with type 2 diabetes mellitus with peripheral neuropathy in our hospital were randomly divided into experimental group and control group, 40 cases in each group. Patients in the control group were treated with methylcobalamin, and patients in the experimental group were given Kudiezi injection. The levels of microcirculation, peripheral nerve score, the incidence of adverse reactions and the therapeutic effect were observed and compared before and after treatment. Results: Compared with those before treatment, the morphological changes of tube loop, the state of tube loop, the state of perirenal loop and the peripheral nerve score in both groups were lower than those before treatment (P <0.05). Compared with the control group, In the experimental group, the morphological changes of tube 管, the state of 管 袢 fluid flow, 袢 Zhou state and the peripheral nerve score were lower, the difference was statistically significant (P <0.05); The incidence of complications in the experimental group was lower than that in the control group Efficacy than the control group, the difference was statistically significant (P <0.05). Conclusion: KDJ injection can improve microcirculation and peripheral nerve in patients with better curative effect and safety.