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感染在致癌性中的作用最近得到两个不同侧面的证据支持。Calvert等研究慢性胃炎与粘膜性淋巴组织(MALT)的胃淋巴瘤之间的相关性,发现某些低、高级胃MALT淋巴瘤中抑制肿瘤基因的DCC和APC的微随体等位基因失衡,但周围炎性粘膜未见此现象。这些变化在结直肠癌的进展中很重要。他们还发现组织学上肯定的慢性胃炎可包括能用聚合酶链反应观察到的单克隆淋巴浸润。幽门螺旋菌(Hpylori,HP)感染的发生率在这份报告中极低(41.7％),可能是附加血清分析增加了HP阳性病例数。总之,慢性胃炎与MALT淋巴瘤之间的相关性现已更加肯定。 未来另一个潜在的重要数据来源是一种
The role of infection in carcinogenicity has recently been supported by two different sides of evidence. Calvert et al. studied the correlation between chronic gastritis and gastric lymphoma of mucosal lymphoid tissue (MALT) and found that the microsatellite alleles of DCC and APC that suppress tumor genes in certain low-grade and high-grade gastric MALT lymphomas are imbalanced. However, this phenomenon is not seen in the surrounding inflammatory mucosa. These changes are important in the progression of colorectal cancer. They also found that histologically confirmed chronic gastritis can include monoclonal lymphoinfiltration that can be observed with the polymerase chain reaction. The incidence of H. pylori (HP) infection was extremely low in this report (41.7%) and it may be that additional serum analysis increased the number of HP-positive cases. In conclusion, the correlation between chronic gastritis and MALT lymphoma is now more certain. Another potential source of important data in the future is