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目的:探讨桥粒芯糖蛋白-1(desmogleinl,Dsg1)在口腔白斑(OLK)及口腔鳞癌(OCSS)中的表达,探讨口腔白斑癌变机制。方法:通过免疫组化法检测35例OLK及30例OESS中Dsg1的表达。结果:OLK组Dsg1表达显著低于正常口腔黏膜组;口腔白斑不典型增生组Dsg1表达显著低于口腔白斑单纯增生组;OSCC组Dsg1表达显著低于OLK组与正常口腔黏膜组;口腔鳞癌组不同分级之间存在显著性差异。结论.Dsg1在口腔黏膜癌变的发生发展过程中可能起到重要作用。
Objective: To investigate the expression of desmoglein-1 (Dsg1) in oral leukoplakia (OLK) and oral squamous cell carcinoma (OCSS) and to explore the mechanism of carcinogenesis in oral leukoplakia. Methods: The expression of Dsg1 in 35 cases of OLK and 30 cases of OESS was detected by immunohistochemistry. Results: Dsg1 expression in OLK group was significantly lower than that in normal oral mucosa group; Dsg1 expression in oral leukoplakia dysplasia group was significantly lower than that in oral leukoplakia group; Dsg1 expression in OSCC group was significantly lower than that in OLK group and normal oral mucosa group; There are significant differences between different grading. in conclusion. Dsg1 may play an important role in the occurrence and development of oral mucosa carcinogenesis.