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用Wistar大鼠模拟高原4000m梭曼中毒,于不同时间收集支气管灌洗液(BALF)进行分析。高原梭曼中毒后BALF中乳酸脱氢酶(LDH)、碱性磷酸酶(AKP)、酸性磷酸酶(ACP)活性以及BALF中细胞数及蛋白质含量,均高于平原中毒组和高原对照组。表明,在模拟高原缺氧和梭曼中毒双重致伤因素作用下可加重肺损伤的程度。
Wistar rats were used to simulate somatic 4000m soman poisoning and bronchoalveolar lavage fluid (BALF) was collected at different times for analysis. The activities of LDH, AKP and ACP in BALF and the number of cells and protein in BALF of BALF after soman poisoning in plateau were higher than those in plains and plateau control groups. It shows that the degree of lung injury can be aggravated under the condition of simulated double injury factors of plateau hypoxia and soman poisoning.