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【目的】探讨不同剂量的右美托咪定复合舒芬太尼在子宫全切术中的镇痛效果。【方法】选取行择期开腹子宫全切术的患者80例，随机分成四组，每组20例。A组（对照组）用舒芬太尼镇痛，B组（低剂量组）用低剂量右美托咪定复合舒芬太尼镇痛，C组（中剂量组）用中剂量右美托咪定复合舒芬太尼镇痛，D组（高剂量组）用高剂量右美托咪定复合舒芬太尼镇痛，通过观察并记录四组不同时点的平均动脉压（MAP）、心率（HR）、脉搏血氧饱和度（SpO2）和呼吸频率（RR），同时记录四组患者不良反应的情况，比较四组的临床镇痛效果。【结果】右美托咪定复合舒芬太尼比单独使用舒芬太尼有更好的镇痛、镇静效果；中剂量组镇痛效果比低剂量组确切、不良反应比高剂量组少。【结论】中剂量的右美托咪定复合舒芬太尼在子宫全切术中有更好的镇痛效果，值得临床推广。“,”[Objective] To explore the analgesic effects of different doses of dexmedetomidine plus sufenta‐nyl on total hysterectomy .[Methods] A total of 80 patients scheduled for elective abdominal hysterectomy were randomly divided into 4 groups ( n=20 each) .Group A (control) received sufentanil analgesia ,group B (low‐dose) composite analgesia of low‐dose dexmedetomidine and sufentanil ,group C (middle‐dose) composite analgesia of middle‐dose dexmedetomidine and sufentanil and D group (high‐dose) composite analgesia of high‐dose dexmedetomidine and sufentanil ,The parameters of mean arterial pressure (MAP) ,heart rate (HR) , oxygen saturation (SpO2 ) and respiratory rate (RR) at different timepoints were recorded .And the adverse reactions of 4 groups were compared .[Results] The analgesic effect of composite analgesia of dexmedetomi‐dine and sufentanil was better than that of sufentanil alone .And the analgesic effect of middle‐dose group was more definite than that of low‐dose group .The adverse reactions of middle‐dose group were fewer than those of high‐dose group .[Conclusion]The regimen of middle‐dose dexmedetomidine plus sufentanil has better anal‐gesic effects during total hysterectomy .And it is worthy of wider popularization .