5—羟甲基糠醛(5—HMF)的量是葡萄糖注射液质量控制的重要指标。5—HMF具有神经毒性,葡萄糖注射液中50%的5-HME能与人体蛋白质结合产生蓄积中毒。中国药典从1985年版起对葡萄糖注射液中5—HMF含量作了限量规定,本文试就5—HMF量的影响因素提出探讨,供制剂生产参考。 1.受热温度、时间的影响 葡萄糖受热分解,产生5—HMF,继而分解 The amount of 5-hydroxymethylfurfural (5-HMF) is an important indicator of the quality control of glucose injections. 5-HMF is neurotoxic and 50% of 5-HME in glucose injection can accumulate into poison with human protein. Chinese Pharmacopoeia since 1985 edition of glucose injection of 5-HMF content limits were made, this paper on the 5-HMF amount of factors that are discussed for the preparation of production reference. 1. Heating temperature, the impact of glucose under the heat decomposition, resulting in 5-HMF, and then decompose