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多数学者认为胃粘膜异型增生(Gastricdysplasia)是胃癌的重要癌前病变,重度异型增生则易发展成癌或与癌并存。八十年代以来陆续见到胃癌单克隆抗体的研究报道,但应用其研究胃粘膜异型增生的报道甚少。本文应用第四军医大学西京医院消化病研究室制备的抗胃癌单克隆抗体MG_7,对59例胃粘膜异型增生、44例胃癌及30例非癌粘膜对照组,用PAP免疫酶染色法进行染色对比,观察胃癌相关抗原在此类胃粘膜中的表达,并就其意义作初步探讨。
Most scholars believe that gastric dysplasia (Gastricdysplasia) is an important precancerous lesion of gastric cancer, and severe dysplasia is easy to develop into cancer or coexist with cancer. Since the 1980s, research reports on monoclonal antibodies to gastric cancer have been reported one after another. However, there have been few reports on the use of gastric cancer dysplasia. The anti-gastric cancer monoclonal antibody MG_7 prepared by the Xijing Hospital Digestive Disease Research Laboratory, Fourth Military Medical University was used to compare the staining of PAP immunostaining method in 59 cases of gastric dysplasia, 44 cases of gastric cancer and 30 cases of non-cancerous mucosa control group. Observe the expression of gastric cancer-associated antigen in these gastric mucosa, and make a preliminary study on its significance.