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目的:探讨年轻卵巢上皮性癌患者的临床特点、治疗及与预后的相关性。方法:对77例<35岁的卵巢上皮性癌患者的临床资料进行回顾性分析。结果:77例35岁以下卵巢上皮性癌患者2年生存率为73.53%,5年生存率为63.19%,以腹痛为最常见首发症状,确诊时Ⅰ期44例,Ⅱ期8例,Ⅲ期22例,Ⅳ期3例。最常见的病理类型为浆液性囊腺癌(32例),以高分化多见(32例),平均肿瘤最大径线为10.7 cm。23例患者保留了生育功能,其中2例于术后成功足月妊娠。临床分期Ⅰ期~Ⅳ期患者的2年生存率分别为94.87%、83.33%、40.00%及0,5年生存率分别为89.74%、50.00%、25.00%及0,Ⅱ期与Ⅲ期患者的生存率无明显统计学差异,各临床分期生存率两两比较均有统计学差异(P<0.05)。临床分期、病理类型、细胞学分级、肿瘤残余大小、肿瘤位于单/双侧对预后有影响(P<0.05),年龄对于预后无影响。肿瘤残余大小是影响预后的独立因素(P<0.05)。结论:35岁以下卵巢上皮性癌妇女临床期别早、分化好,预后相对较好,临床分期、病理类型、细胞学分级、肿瘤残余大小、肿瘤位于单/双侧对预后有影响,年龄对于预后无影响。肿瘤残余大小是影响预后的独立因素。
Objective: To investigate the clinical features, treatment and prognosis of young patients with epithelial ovarian cancer. Methods: The clinical data of 77 patients <35 years old with epithelial ovarian cancer were analyzed retrospectively. Results: The 2-year survival rate of 77 patients with epithelial ovarian cancer under 35 years old was 73.53%, and the 5-year survival rate was 63.19%. The most common symptom was abdominal pain. 44 cases were stage Ⅰ, 8 cases were stage Ⅱ, 22 cases, Ⅳ in 3 cases. The most common pathological type of serous cystadenocarcinoma (32 cases), with high differentiation more common (32 cases), the average diameter of the largest tumor line was 10.7 cm. Twenty-three patients retained fertility and 2 of these patients had full-term pregnancy after surgery. The 2-year survival rates of stage Ⅰ-Ⅳ patients in clinical stage were 94.87%, 83.33%, 40.00% and 0, 5-year survival rates were 89.74%, 50.00%, 25.00% and 0, respectively There was no statistically significant difference in survival rate between the two groups (P <0.05). The clinical stage, pathological type, cytological grade, tumor residual size, tumor located on the single / bilateral have an impact on prognosis (P <0.05), and age has no effect on the prognosis. The residual tumor size was an independent factor affecting the prognosis (P <0.05). Conclusion: Women with ovarian epithelial carcinoma under 35 years old have early clinical stages, well differentiated and relatively good prognosis. The clinical stage, pathological type, cytological grade, tumor residual size and the tumor located on the single / bilateral sides have an impact on the prognosis. No effect on prognosis. Tumor residual size is an independent factor affecting the prognosis.