组织细胞增生症X包括Letterer-Siwe病、Hand-Schüuer-Christian病和嗜酸性肉芽肿。前二种病较常见于婴儿和幼儿,其病程呈急性或慢性。黄疸可见于急性型和慢性型的后期,并被认为是一个予后不良的体征。作者报道了七年中观察到的6个儿童患者,男性5例、女性1例,均有提示组织细胞增生症X的肝外表现, Histocytosis X includes Letterer-Siwe disease, Hand-Schueruer-Christian disease and eosinophilic granuloma. The first two diseases are more common in infants and young children, the course of the disease was acute or chronic. Jaundice is seen in the later stages of acute and chronic forms and is considered a sign of poor prognosis. The authors reported 6 childhood patients observed in seven years, 5 males and 1 females, all of whom had extrahepatic manifestations of histiocytosis X,