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目的:探讨立体定向放射治疗原发性肝癌的临床效果。方法:选择收治的原发性肝癌患者100例,均实施立体定向放射治疗,回顾分析临床资料。结果:本组100例患者中,治疗后2个月随访显示,CR 16例,PR 64例,SD 18例,PD 2例,临床总有效率为80.0%。患者术后多有Ⅰ级消化道反应,表现为食欲不振、腹部不适等,完成治疗后可自行缓解;少数有Ⅱ级消化道反应,积极对症治疗后消失,无肝、肾等严重损伤发生。随访2年显示,肿瘤<5cm患者1年、2年生存率显著高于5～10cm及≥10cm的患者,差异有统计学意义。结论:原发性肝癌采用立体定向放射治疗,可显著提高临床总有效率,延长患者生存期,改善生活质量,具有较高的安全性和有效性,值得在临床广泛推广应用。
Objective: To investigate the clinical effect of stereotactic radiotherapy on primary liver cancer. Methods: 100 patients with primary liver cancer were selected for treatment. Stereotactic radiotherapy was performed and the clinical data were retrospectively analyzed. Results: Of the 100 patients in this study, follow-up of 2 months after treatment showed that 16 cases were CR, 64 cases were PR, 18 cases were SD and 2 cases were PD. The total clinical effective rate was 80.0%. Patients with grade Ⅰ gastrointestinal reactions, manifested as loss of appetite, abdominal discomfort, complete self-remission after treatment; a few grade Ⅱ gastrointestinal reactions, positive symptomatic treatment disappeared, no liver, kidney and other serious injuries. The follow-up of 2 years showed that the 1-year and 2-year survival rates of patients with tumors <5cm were significantly higher than those of patients with 5 ~ 10cm and ≥10cm, the difference was statistically significant. Conclusion: Stereotactic radiotherapy for primary hepatocellular carcinoma can significantly improve the total effective rate, extend the survival of patients and improve the quality of life, with high safety and effectiveness, which is worthy of wide application in clinic.