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早在1924年便有作者观察到剧烈运动后引起的代谢性酸中毒是乳酸堆积所造成,称为乳酸酸中毒(Lactic acid acidosis),此后发现在婴儿腹泻、缺氧、大出血、内毒素休克、体外循环灌注不足、高热、过度换气、酒精中毒、非酮症性糖尿病酸中毒时也会出现乳酸酸中毒。1961年Hackabee总结了严重乳酸酸中毒病例,认为部分可找到原发病,有的则原因不明,提出将乳酸酸中毒分为特发性和继发性两种,由于本症有较高的死亡率(50～80％),故临床医师应对本病引起重视,以获得早期诊断和治疗,减少发病和死亡。
As early as 1924, one of the authors observed that the metabolic acidosis caused by strenuous exercise is caused by the accumulation of lactic acid, called Lactic acidosis. Later on, it was found that in infants with diarrhea, hypoxia, haemorrhage, endotoxic shock, Inadequate perfusion of extracorporeal circulation, fever, hyperventilation, alcoholism, nonketotic acidosis may also occur when lactic acidosis. In 1961 Hackabee summed up serious cases of lactic acidosis, that part of the original disease can be found, while others are unknown reasons, the proposed lactic acidosis is divided into idiopathic and secondary, due to the high mortality of this disease Rate (50 ~ 80%), so clinicians should pay attention to the disease, in order to obtain early diagnosis and treatment, reduce morbidity and mortality.