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目的探讨联合检测C反应蛋白(CRP)、红细胞沉降率(ESR)在诊断在高血压、冠状动脉粥样硬化性心脏病(CHD)患者中的临床价值。方法选取2014年1-8月抚顺矿务局总医院收治的152例高血压患者和150例CHD患者作为研究对象,另选取100名同期健康体检者作为对照组,测定3组检测者的血清CRP和ESR水平。结果高血压组及CHD病组检测者的血清CRP和ESR水平均明显高于对照组,差异均有统计学意义(均P<0.05);其中Ⅲ级高血压患者的血清CRP和ESR水平均明显高于Ⅰ、Ⅱ级患者,CHD组心力衰竭Ⅲ度组患者的CRP和ESR水平均明显高于心力衰竭Ⅰ度、Ⅱ度、无心力衰竭组,差异均有统计学意义(均P<0.05)。结论 CRP和ESR是反映炎症的敏感性指标,在炎性反应早期可迅速升高,CRP与ESR联合检测对诊断高血压、CHD具有重要临床价值。
Objective To investigate the clinical value of combined detection of C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) in the diagnosis of hypertension and coronary heart disease (CHD). Methods A total of 152 hypertensive patients and 150 CHD patients were enrolled in the General Hospital of Fushun Mining Bureau from January to August 2014. 100 healthy subjects of the same period were selected as the control group. Serum CRP And ESR levels. Results The levels of serum CRP and ESR in hypertension group and CHD group were significantly higher than those in control group (all P <0.05). The levels of serum CRP and ESR in patients with hypertension were significantly higher than those in control group The CRP and ESR levels in patients with grade Ⅲ heart failure in CHD group were significantly higher than those in patients with grade Ⅰ and Ⅱ heart failure (grade Ⅰ, Ⅱ, no heart failure) (all P <0.05) . Conclusion CRP and ESR reflect the sensitivity of inflammation and can be rapidly increased in the early stage of inflammatory reaction. Combined detection of CRP and ESR has important clinical value in the diagnosis of hypertension and CHD.