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目的:探讨正常孕妇、妊高症患者血浆D-二聚体水平及其检测意义。方法:选取50例妊娠高血压综合征患者,同时选取同期健康产检孕妇作为对照组,使用全自动血凝检测仪,通过免疫比浊法检测两组孕妇D-二聚体水平,比较各组间凝血指标(PT、APTT、Fib)和D-D水平、各组间免疫指标(C3、C4、IgA、IgG、IgM)。结果:和正常妊娠组对比,妊娠高血压组PT和APTT值明显更小,Fib和D-D水平明显更高,P<0.05。在妊娠高血压组内,和轻度子痫前期对比,重度子痫前期、子痫PT和APTT值明显更小,Fib和D-D水平明显更高,P<0.05。和重度子痫前期对比,子痫PT和APTT值明显更小,Fib和D-D水平明显更高,P<0.05。正常妊娠组、轻度子痫三组C3、C4、IgA、IgG、IgM无明显差异,P>0.05。和正常晚期妊娠组对比,重度子痫前期C3、IgG、IgM明显更低,子痫C3、C4、IgA、IgG、IgM明显更低,P<0.05。结论:血浆D-二聚体水平能够有效地预测妊娠高血压综合征患者的病情和预后情况,具有重要的临床意义。
Objective: To investigate the level of plasma D-dimer and its significance in normal pregnant women and patients with pregnancy-induced hypertension. Methods: Fifty patients with pregnancy-induced hypertension (Hypertension syndrome) were selected. At the same time, healthy pregnant women of the same period were selected as the control group. The levels of D-dimer in the two groups of pregnant women were measured by the immunoturbidimetric method. The indexes of coagulation (PT, APTT, Fib) and DD, the immune indexes (C3, C4, IgA, IgG, IgM) among the groups. Results: Compared with the normal pregnancy group, the PT and APTT values in pregnancy-induced hypertension group were significantly smaller and the levels of Fib and D-D were significantly higher (P <0.05). Compared with mild preeclampsia, the PT and APTT values in preeclampsia and preeclampsia in pregnancy-induced hypertension group were significantly smaller, and the levels of Fib and D-D were significantly higher (P <0.05). Compared with severe preeclampsia, the values of PT and APTT in preeclampsia were significantly smaller and the levels of Fib and D-D were significantly higher (P <0.05). There were no significant differences in C3, C4, IgA, IgG, IgM between normal pregnancy group and mild eclampsia group (P> 0.05). Compared with the normal group, the levels of C3, IgG and IgM in severe preeclampsia were significantly lower, and the levels of C3, C4, IgA, IgG and IgM in eclampsia were significantly lower (P <0.05). Conclusion: The level of plasma D-dimer can effectively predict the condition and prognosis of patients with pregnancy induced hypertension syndrome. It has important clinical significance.