论文部分内容阅读
目的探讨尿标本中视黄醇结合蛋白(RBP)、微量白蛋白(mALB)、IV型胶原(IV-C)检测在糖尿病肾病早期诊断中的作用。方法用ELSA法检测尿中RBP、IV-C,免疫比浊法检测mALB,Jaffe法测定肌酐。结果正常对照组RBP/Cre及IV-C的含量分别为2.12±0.95mg/mmol、44.68±17.2ng/ml。在糖尿病无肾病组中,mALB的含量与正常对照组相近(P>0.05),而RBP、IV-C的含量与正常对照组相比有显著差别(P<0.05)。糖尿病的初期肾病组和临床肾病组的RBP/Cr、mALB、IV-C的含量均明显高于对照组(P<0.01)。结论联合检测尿RBP、IV-C是诊断糖尿病肾病早期损伤灵敏、可靠的实验室指标。
Objective To investigate the role of RBP, mALB and IV-C in the early diagnosis of diabetic nephropathy. Methods Urinary RBP and IV-C were detected by ELSA method. MALB was detected by turbidimetry and creatinine was measured by Jaffe method. Results The contents of RBP / Cre and IV-C in normal control group were 2.12 ± 0.95 mg / mmol and 44.68 ± 17.2 ng / ml, respectively. The content of mALB in diabetic nephropathy group was similar to that in normal control group (P> 0.05), while the content of RBP and IV-C was significantly different from that in normal control group (P <0.05). The levels of RBP / Cr, mALB and IV-C in the primary nephropathy group and the clinical nephropathy group were significantly higher than those in the control group (P <0.01). Conclusions Combined detection of urinary RBP and IV-C is a sensitive and reliable laboratory indicator for early diagnosis of diabetic nephropathy.