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国产新药利福定,化学名为异丁基哌嗪力复霉素,英文名为(3—4—lsobutyI—1—piperazinyl)rifamycinsv。本药与利福平是同一类型的化合物,只是在奈环C~3侧链上的取代基团不同,前者为异丁基,后者为甲基,但利福定对结核杆菌,麻风杆菌等分枝杆菌活性较利福平为高,而毒付作用较少,本文从细胞,亚细胞及分子水平上初步探讨了两药的抗菌作用方式的同异。用常规的二倍稀释法比较了两药对大肠杆菌及金色葡萄球菌209p的抗菌活性,可见两药对阴性菌的Mlc较高,其Mlc一般为1.56ug/ml～6.25ug/ml之间,MBC为12.5～25ug/
Domestic new drug rifadin, chemical name is isobutylpiperazine fructus, English name (3-4-lsobutyI-1-piperazinyl) rifamycinsv. The drug and rifampicin are the same type of compound, but in the ring Chennai C ~ 3 side chain on the different groups, the former isobutyl, which is methyl, but rifamycin Mycobacterium tuberculosis, Leprosy Mycobacterium tuberculosis activity than rifampicin for high, and the role of poison less, this paper from the cellular, subcellular and molecular level to explore the two antibacterial effect of the same way. The antibacterial activity of the two drugs against E. coli and S. aureus 209p was compared with the conventional two-fold dilution method. It can be seen that the Mlc of the two drugs is higher than that of the negative bacteria, and the Mlc is generally between 1.56ug / ml and 6.25ug / ml, MBC is 12.5 ~ 25ug /