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目的探讨环境铅暴露对学龄前儿童血铅及脂质过氧化水平的影响。方法采用分层整群抽样法,抽取辽宁省鞍山市5所托幼机构的408名学龄前儿童,其中男童217名,女童192名。检测血铅、全血δ-氨基γ-戊二酸脱水酶(ALAD)、超氧化物歧化酶(SOD)、还原型谷胱甘肽(GSH)、谷胱甘肽过氧化物酶(GSH-Px)和血清丙二醛(MDA)。结果鞍山市儿童铅中毒发生率为27.4%;血铅≥100μg/L的儿童ALAD活性为(644.50±146.17)u/(g.Hb),与血铅<100μg/L的儿童比较明显降低,MDA水平达(5.875±0.818)nmol/mL,与血铅<100μg/L的儿童比较明显升高;被调查儿童的SOD、GSH-Px、GSH水平与血铅升高无关联。结论ALAD和MDA是反映铅致氧化损伤的敏感指标。
Objective To investigate the effects of environmental lead exposure on blood lead and lipid peroxidation in preschool children. Methods By stratified cluster sampling method, 408 preschool children were selected from 5 nurseries in Anshan City, Liaoning Province, including 217 boys and 192 girls. Blood lead, whole blood δ-amino gamma glutaric acid dehydratase (ALAD), superoxide dismutase (SOD), reduced glutathione (GSH), glutathione peroxidase (GSH- Px) and serum malondialdehyde (MDA). Results The prevalence of lead poisoning in children was 27.4% in Anshan City. The ALAD activity in children with blood lead level ≥100μg / L was (644.50 ± 146.17) u / (g.Hb), significantly lower than that in children with blood lead level <100μg / L, MDA The level of (5.875 ± 0.818) nmol / mL was significantly higher than that of children with blood lead <100μg / L. There was no correlation between the levels of SOD, GSH-Px, GSH and blood lead in the investigated children. Conclusion ALAD and MDA are sensitive indicators of lead-induced oxidative damage.