An analysis of trace elements and isotopic geochemistry suggest that the ore-forming materials of golddeposits in the Jiaodong granite-greenstone belt have multiple sources, especially the mantle source. Seismic wave,magnetic and gravity fields show that the crust-mantle structure and its coupling mechanism are the fundamental dynamiccauses for the exchange and accumulation of materials and energy in the metallogenic system. Considering the evolutionhistory of the structural setting, the tectono-metallogenic dynamics model of the area can be summarized as follows: (1)occurrence of the greenstone belt during the Archean-Proterozoic-the embryonic form of Au-source system; (2) stabletectonic setting in the Paleozoic-an intermittence in gold mineralization; (3) intensive activation and reformation of thegreenstone belt in the Mesozoic-ectono-mineralization and tectono-diagensis; (4) posthumous structural activity in theCenozoic-destruction of orebodies in the later stage. In the middle and late Indosinian, the Tancheng-Lujiang fault zonecut deeply into the upper mantle so that the ore-bearing fluids migrated to higher layers through the crust-mantleinteraction, resulting in alteration and mineralization.