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目的 :从神经电生理角度 ,观察过度训练对大鼠中枢及外周神经系统机能状态的影响及补肾中药的调节作用。方法 :采用跑台 8周递增负荷训练 ,制备大鼠过度训练模型。以听觉脑干诱发电位(ABR)、体感诱发电位(SEP)、腓肠肌神经 -肌肉兴奋传递的绝对不应期 (ARP)为指标 ,比较观察训练前后正常组、训练组和补肾组动物中枢神经系统 (CNS)机能状况。结果 :8周递增负荷训练使大鼠血睾酮 (T)、血红蛋白 (Hb)下降 ,血尿素氮 (BUN)升高 ;神经系统机能下降 ,表现为造模后ABR、SEP的峰潜伏期延长 ,ABR阈值提高 ;腓肠肌ARP延长。而补肾中药对过度训练引起的血生化指标和神经系统功能的下降从平均值看有一定改善作用 ,但部分指标统计学上无显著性差异。结论 :过度训练能引起神经系统功能下降 ,补肾中药可使其得到一定改善 ,其作用机理可能与改善下丘脑 -垂体 -性腺轴对神经系统的影响有关
Objective: To observe the effect of overtraining on the functional status of central and peripheral nervous system in rats and the regulatory effect of kidney-reinforcing traditional Chinese medicine (TCM) from the perspective of electrophysiology. Methods: Rats’ overtraining model was prepared using 8-week incremental load training. The auditory brainstem evoked potential (ABR), somatosensory evoked potential (SEP), and absolute refractory period (ARP) of gastrocnemius muscle-muscle excitatory transmission were used as indicators to compare the central nervous system of the normal, training, and kidney-building groups before and after training. (CNS) performance status. RESULTS: Eight weeks of incremental training led to a decrease in blood testosterone (T), hemoglobin (Hb), and elevated blood urea nitrogen (BUN); neurological function was decreased, showing an extended peak latency of ABR and SEP after modeling. Increased threshold; prolonged ARP of gastrocnemius muscle. The decrease of blood biochemical and neurological function caused by over-training of kidney-busting herbs has a certain improvement from the average value, but there is no statistically significant difference in some indicators. Conclusion: Overtraining can cause a decline in nervous system function. Bushen Chinese medicine can improve it, and its mechanism of action may be related to the improvement of the hypothalamic-pituitary-gonadal axis on the nervous system.